Luuydinlipidien kirjo

https://www.ncbi.nlm.nih.gov/pubmed/26774740

Acad Radiol. 2016 Mar;23(3):273-83. doi: 10.1016/j.acra.2015.11.009. Epub 2016 Jan 7.

Bone Marrow Lipid Profiles from Peripheral Skeleton as Potential Biomarkers for Osteoporosis: A 1H-MR Spectroscopy Study.

Di Pietro G¹, Capuani S², Manenti G³, Vinicola V⁴, Fusco A³, Baldi J⁵, Scimeca M⁶, Hagberg G⁷, Bozzali M⁸, Simonetti G³, Tarantino U⁵.

RESULTS:

The reproducibility was satisfactory. In femoral neck, methylene (L13), glycerol (L41, L43), and total lipid resonances were significantly lower in healthy as compared to osteoporotic subjects. On the other hand, in calcaneus, L13/glycerol significantly discriminated between osteopenic and osteoporotic subjects whereas L13/(unsaturated lipid) discriminated between healthy and osteopenic group. However, the reproducibility of both unsaturated lipid and glycerol resonances were less optimal.

CONCLUSIONS:

MRS of bone marrow lipid profiles from peripheral skeletal sites may be a promising tool for screening of large population to identify individuals with or at risk for developing osteoporosis. Moreover, it provides information about the metabolic changes occurring in bone marrow with the development of osteoporosis, which are skeletal site dependent.