Luukorvikemateriaalin kehittelystä ( alfa-TCP, CO3Ap, PCL)

https://www.ncbi.nlm.nih.gov/pubmed/26225725

Biomed Mater. 2015 Jul 30;10(4):045011. doi: 10.1088/1748-6041/10/4/045011.

Development of a bone substitute material based on alpha-tricalcium phosphate scaffold coated with carbonate apatite/poly-epsilon-caprolactone.

Bang LT¹, Ramesh S, Purbolaksono J, Long BD, Chandran H, Ramesh S, Othman R.

Abstract

Interconnected porous tricalcium phosphate ceramics are considered to be potential bone substitutes. However, insufficient mechanical properties when using tricalcium phosphate powders remain a challenge. To mitigate these issues, we have developed a new approach to produce an interconnected alpha-tricalcium phosphate (α-TCP) scaffold and to perform surface modification on the scaffold with a composite layer, which consists of hybrid carbonate apatite / poly-epsilon-caprolactone (CO3Ap/PCL) with enhanced mechanical properties and biological performance. Different CO3Ap combinations were tested to evaluate the optimal mechanical strength and in vitro cell response of the scaffold. The α-TCP scaffold coated with CO3Ap/PCL maintained a fully interconnected structure with a porosity of 80% to 86% and achieved an improved compressive strength mimicking that of cancellous bone. The addition of CO3Ap coupled with the fully interconnected microstructure of the α-TCP scaffolds coated with CO3Ap/PCL increased cell attachment, accelerated proliferation and resulted in greater alkaline phosphatase (ALP) activity. Hence, our bone substitute exhibited promising potential for applications in cancellous bone-type replacement.

PMID:

26225725

DOI:

10.1088/1748-6041/10/4/045011

[PubMed - indexed for MEDLINE]