LNX2 (13q12.2) PDZRN1, Numb binding protein X2,

LNX2
 https://www.ncbi.nlm.nih.gov/gene/?term=PDZRN1

Preferred Names

ligand of Numb protein X 2

Names

PDZ domain containing ring finger 1

PDZ domain-containing RING finger protein 1

numb-binding protein 2

Related articles in PubMed

1. Genetic amplification of the NOTCH modulator LNX2 upregulates the WNT/β-catenin pathway in colorectal cancer. Camps J, et al. Cancer Res, 2013 Mar 15. PMID 23319804, Free PMC Article
2. The ligands of Numb proteins X1 and X2 are specific markers for chronic Q fever. Mehraj V, et al. FEMS Immunol Med Microbiol, 2012 Feb. PMID 22066909
3. Structural basis for the indispensable role of a unique zinc finger motif in LNX2 ubiquitination. Nayak D, et al. Oncotarget, 2015 Oct 27. PMID 26451611, Free PMC Article
4. Ligand of Numb proteins LNX1p80 and LNX2 interact with the human glycoprotein CD8α and promote its ubiquitylation and endocytosis. D'Agostino M, et al. J Cell Sci, 2011 Nov 1. PMID 22045731
5. Common variants on 14q32 and 13q12 are associated with DLBCL susceptibility. Kumar V, et al. J Hum Genet, 2011 Jun. PMID 21471979

See all (32) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

1. FOXC2 or its associated gene expression program may provide an effective target for anti-EMT-based therapies for the treatment of claudin-low/basal B breast tumors or other EMT-/CSC-enriched tumors
2. The authors found a high level of LNX1 and LNX2 mRNAs in endocarditis, the principal manifestation of chronic Q fever, but not in acute Q fever.
3. LNX1 and LNX2 interact with CD8alpha and promote its ubiquitylation and endocytosis

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