Luustosta

måndag 3 december 2018

LNX5 (Xq28) LU1, PDZK4, PDZRN4L

https://www.ncbi.nlm.nih.gov/gene/?term=LNX5

: LU1; LNX5; PDZK4; PDZRN4L
Expression Biased expression in brain (RPKM 47.1), spleen (RPKM 4.7) and 4 other tissues See more

Preferred Names: PDZ domain-containing protein 4

Names: PDZ domain-containing RING finger protein 4-like protein

https://www.ncbi.nlm.nih.gov/protein/NP_001290442.1

Conserved Domains (1) summary

smart00228 Location:144 → 220: PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

NP_001290441.1 PDZ domain-containing 4 isoform 1

LOCUS       NP_001290442             673 aa            linear   PRI 30-JUN-2018
DEFINITION  PDZ domain-containing protein 4 isoform 3 [Homo sapiens].
ACCESSION   NP_001290442
VERSION     NP_001290442.1
DBSOURCE    REFSEQ: accession NM_001303513.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 673)
  AUTHORS   Nagayama S, Iiizumi M, Katagiri T, Toguchida J and Nakamura Y.
  TITLE     Identification of PDZK4, a novel human gene with PDZ domains, that
            is upregulated in synovial sarcomas
  JOURNAL   Oncogene 23 (32), 5551-5557 (2004)
   PUBMED   15077175
  REMARK    GeneRIF: Might play an important role in the proliferation of SS
            cells and might be a suitable target for SS drugs.
REFERENCE   2  (residues 1 to 673)
  AUTHORS   Katoh M and Katoh M.
  TITLE     Identification and characterization of human PDZRN4L gene and mouse
            Pdzrn4l gene in silico
  JOURNAL   Int. J. Mol. Med. 13 (6), 923-927 (2004)
   PUBMED   15138636
  REMARK    GeneRIF: PDZRN4L showed 49.9% total-amino-acid identity with PDZRN4
            short isoform (PDZRN4S).  PDZ, PR34H1 and PR34H2 domains were
            conserved between PDZRN4L and PDZRN4S.
REFERENCE   3  (residues 1 to 673)
  AUTHORS   Sandoval N, Bauer D, Brenner V, Coy JF, Drescher B, Kioschis P,
            Korn B, Nyakatura G, Poustka A, Reichwald K, Rosenthal A and
            Platzer M.
  TITLE     The genomic organization of a human creatine transporter (CRTR)
            gene located in Xq28
  JOURNAL   Genomics 35 (2), 383-385 (1996)
   PUBMED   8661155
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK127016.1, BC143542.1 and BC002606.2.
            
            Transcript Variant: This variant (3) contains an alternate exon in
            the 5' coding region and initiates translation at an alternate
            start codon, compared to variant 1. The encoded isoform (3) has a
            distinct N-terminus and is shorter than isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC143542.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000350]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..673
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq28"
     Protein         1..673
                     /product="PDZ domain-containing protein 4 isoform 3"
                     /note="PDZ domain-containing protein 4; PDZ
                     domain-containing RING finger protein 4-like protein"
                     /calculated_mol_wt=75218
     Region          42..118
                     /region_name="PDZ"
                     /note="Domain present in PSD-95, Dlg, and ZO-1/2;
                     smart00228"
                     /db_xref="CDD:214570"
     Site            order(45..48,50,99..100,103..104)
                     /site_type="other"
                     /note="protein binding site [polypeptide binding]"
                     /db_xref="CDD:238492"
     CDS             1..673
                     /gene="PDZD4"
                     /gene_synonym="LNX5; LU1; PDZK4; PDZRN4L"
                     /coded_by="NM_001303513.1:819..2840"
                     /note="isoform 3 is encoded by transcript variant 3"
                     /db_xref="GeneID:57595"
                     /db_xref="HGNC:HGNC:21167"
                     /db_xref="MIM:300634"
ORIGIN      
        1 mtappishey ydpaefmegg pqeadrldel eyeevelyks shrdklglmv cyrtddeedl
       61 giyvgevnpn siaakdgrir egdriiqing vdvqnreeav ailsqeentn isllvarpes
      121 qlakrwkdsd rddflddfgs enegelrark lksppaqqpg neeekgapda gpglsnsqel
      181 dsgvgrtdes trneessehd llgdeppsst ntpgslrkfg lqgdalqsrd fhfsmdslla
      241 egaglgggdv pgltdeeyer yrelleikch lengnqlgll fprasggnsa ldvnrneslg
      301 hemamleeel rhlefkcrni lraqkmqqlr ercmkawlle eeslydlaas epkkhelsdi
      361 selpeksdkd stsayntges crstpllvep lpesplrram agnsnlnrtp pgpavatpak
      421 aapppgspak frslsrdpea grrqhaeerg rrnpktgltl ervgpesspy lsrrhrgqgq
      481 egehyhscvq laptrgleel ghgplslagg prvggvaaaa teaprmewkv kvrsdgtryv
      541 akrpvrdrll karalkiree rsgmttddda vsemkmgryw skeerkqhli rareqrkrre
      601 fmmqsrlecl reqqngdskp elniialshr ktmkkrnkki ldnwitiqem lahgarsadg
      661 krvynpllsv ttv
//

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Luumassaan vaikuttava järjestelmä Numb- LNX , joten otan näitä geenejä Luustoblogiin

https://www.researchgate.net/figure/Domain-structures-of-mammalian-LNX-proteins-LNX1-and-LNX2-share-an-identical-domain_fig1_51558005

LNX2 (13q12.2) PDZRN1, Numb binding protein X2,

LNX2
https://www.ncbi.nlm.nih.gov/gene/?term=PDZRN1

Preferred Names: ligand of Numb protein X 2

Names: PDZ domain containing ring finger 1; PDZ domain-containing RING finger protein 1; numb-binding protein 2

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Submit: New GeneRIF Correction

LNX1 (4q12) MPDZ, PDZRN2 , multi-PDZ-domain conaining protein , E3 ubiquitin ligase , numb- binding protein1,

https://www.ncbi.nlm.nih.gov/gene/?term=PDZRN2

LNX; MPDZ; PDZRN2
Summary: This gene encodes a membrane-bound protein that is involved in signal transduction and protein interactions. The encoded product is an E3 ubiquitin-protein ligase, which mediates ubiquitination and subsequent proteasomal degradation of proteins containing phosphotyrosine binding (PTB) domains. This protein may play an important role in tumorogenesis. Alternatively spliced transcript variants encoding distinct isoforms have been described. A pseudogene, which is located on chromosome 17, has been identified for this gene. [provided by RefSeq, Jul 2008]
ExpressionUbiquitous expression in brain (RPKM 10.1), esophagus (RPKM 8.0) and 25 other tissues


Preferred Names: E3 ubiquitin-protein ligase LNX

Names: PDZ domain-containing ring finger protein 2; RING-type E3 ubiquitin transferase LNX; ligand of numb-protein X 1, E3 ubiquitin protein ligase; multi-PDZ-domain-containing protein, E3 ubiquitin-protein ligase LNX; numb-binding protein 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

LNX- geeniperhe E3 ubikitiiniligaaseja . Molekyylievoluutiota. (Numb- binding proteins)

2011 Aug 9;11:235. doi: 10.1186/1471-2148-11-235.
https://www.researchgate.net/figure/Domain-structures-of-mammalian-LNX-proteins-LNX1-and-LNX2-share-an-identical-domain_fig1_51558005

Molecular evolution of the LNX gene family.

Flynn M¹, Saha O, Young P.Abstract

BACKGROUND:

LNX (Ligand of Numb Protein-X) proteins typically contain an amino-terminal RING domain adjacent to either two or four PDZ domains - a domain architecture that is unique to the LNX family. LNX proteins function as E3 ubiquitin ligases and their domain organisation suggests that their ubiquitin ligase activity may be targeted to specific substrates or subcellular locations by PDZ domain-mediated interactions. Indeed, numerous interaction partners for LNX proteins have been identified, but the in vivo functions of most family members remain largely unclear.

RESULTS:

To gain insights into their function we examined the phylogenetic origins and evolution of the LNX gene family. We find that a LNX1/LNX2-like gene arose in an early metazoan lineage by gene duplication and fusion events that combined a RING domain with four PDZ domains. These PDZ domains are closely related to the four carboxy-terminal domains from multiple PDZ domain containing protein-1 (MUPP1). Duplication of the LNX1/LNX2-like gene and subsequent loss of PDZ domains appears to have generated a gene encoding a LNX3/LNX4-like protein, with just two PDZ domains. This protein has novel carboxy-terminal sequences that include a potential modular LNX3 homology domain. The two ancestral LNX genes are present in some, but not all, invertebrate lineages. They were, however, maintained in the vertebrate lineage, with further duplication events giving rise to five LNX family members in most mammals. In addition, we identify novel interactions of LNX1 and LNX2 with three known MUPP1 ligands using yeast two-hybrid asssays. This demonstrates conservation of binding specificity between LNX and MUPP1 PDZ domains.

CONCLUSIONS:

The LNX gene family has an early metazoan origin with a LNX1/LNX2-like protein likely giving rise to a LNX3/LNX4-like protein through the loss of PDZ domains. The absence of LNX orthologs in some lineages indicates that LNX proteins are not essential in invertebrates. In contrast, the maintenance of both ancestral LNX genes in the vertebrate lineage suggests the acquisition of essential vertebrate specific functions. The revelation that the LNX PDZ domains are phylogenetically related to domains in MUPP1, and have common binding specificities, suggests that LNX and MUPP1 may have similarities in their cellular functions.

PMID:: 21827680
PMCID:: PMC3162930
DOI:: 10.1186/1471-2148-11-235

[Indexed for MEDLINE]

Free PMC Article

LNX3 (3p13) PDZRN3, SEMCAP3 ( HPV virus E6p tuhonnee tämän proteiinin)

https://www.ncbi.nlm.nih.gov/gene/23024

LNX3; SEMCAP3; SEMACAP3
Summary: This gene encodes a member of the LNX (Ligand of Numb Protein-X) family of RING-type ubiquitin E3 ligases. This protein may function in vascular morphogenesis and the differentiation of adipocytes, osteoblasts and myoblasts. This protein may be targeted for degradation by the human papilloma virus E6 protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
Expression: Broad expression in ovary (RPKM 21.4), endometrium (RPKM 16.6) and 20 other tissues See more
Orthologs mouse all

Preferred Names: E3 ubiquitin-protein ligase PDZRN3

Names: RING-type E3 ubiquitin transferase PDZRN3; ligand of Numb protein X 3; likely ortholog of mouse semaF cytoplasmic domain associated protein 3; semaphorin cytoplasmic domain-associated protein 3

NP_001290068.1

EC 2.3.2.27

Structure, history:

NP_0012900 8.1 E3 ubiquitin-protein ligase PDZRN3 isoform 2

Conserved Domains (2) summary

smart00228 Location:5 → 36: PDZ; Domain pres

nt in PSD-95, Dlg, and ZO-1/2

cd00992 Location:118 → 186: PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein int

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Submit: New GeneRIF Correction

LNX4 (12q12) PDZRN4, SAMCAP3L,Ligand of Numb protein X4 (antituumoriproteiini)

https://www.ncbi.nlm.nih.gov/gene/29951

Also known as: LNX4; SAMCAP3L
Expression: Broad expression in prostate (RPKM 5.3), urinary bladder (RPKM 3.3) and 15 other tissues See more
Orthologs mouse all

Preferred Names: PDZ domain-containing RING finger protein 4

Names: IMAGE5767589; SEMACAP3-like protein; ligand of Numb protein X 4

Structure, history

https://www.ncbi.nlm.nih.gov/protein/NP_001158067.1

Conserved Domains (4) summary

smart00228 Location:221 → 313: PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00162 Location:17 → 5

40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

cd00992 Location:402 → 484: PDZ_signaling; PDZ do

d binding to internal (non-C-terminal) ...

cl19105 Location:66 → 108: Sina; Seven in absentia (Sina) protein family, C-terminal substrate binding domain; composed of the Drosophila Sina protein, the mammalian Sina homolog (Siah), the plant protein SINAT5, and similar proteins. Sina, Siah and SINAT5 are RING-containing proteins ...

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Submit: New GeneRIF Correction

Luustosta

Etiketter

måndag 3 december 2018

LNX5 (Xq28) LU1, PDZK4, PDZRN4L

Related articles in PubMed

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Luumassaan vaikuttava järjestelmä Numb- LNX , joten otan näitä geenejä Luustoblogiin

LNX2 (13q12.2) PDZRN1, Numb binding protein X2,

Related articles in PubMed

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

LNX1 (4q12) MPDZ, PDZRN2 , multi-PDZ-domain conaining protein , E3 ubiquitin ligase , numb- binding protein1,

Related articles in PubMed

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

LNX- geeniperhe E3 ubikitiiniligaaseja . Molekyylievoluutiota. (Numb- binding proteins)

Molecular evolution of the LNX gene family.

BACKGROUND:

RESULTS:

CONCLUSIONS:

LNX3 (3p13) PDZRN3, SEMCAP3 ( HPV virus E6p tuhonnee tämän proteiinin)

Structure, history:

NP_0012900 8.1 E3 ubiquitin-protein ligase PDZRN3 isoform 2

Related articles in PubMed

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

LNX4 (12q12) PDZRN4, SAMCAP3L,Ligand of Numb protein X4 (antituumoriproteiini)

Related articles in PubMed

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Etiketter

måndag 3 december 2018

Related articles in PubMed

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Related articles in PubMed

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Related articles in PubMed

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Molecular evolution of the LNX gene family.

BACKGROUND:

RESULTS:

CONCLUSIONS:

Structure, history:

NP_00129008.1 E3 ubiquitin-protein ligase PDZRN3 isoform 2

Related articles in PubMed

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Related articles in PubMed

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NP_0012900 8.1 E3 ubiquitin-protein ligase PDZRN3 isoform 2