LNX1 (4q12) MPDZ, PDZRN2 , multi-PDZ-domain conaining protein , E3 ubiquitin ligase , numb- binding protein1,

https://www.ncbi.nlm.nih.gov/gene/?term=PDZRN2

LNX; MPDZ; PDZRN2

Summary

This gene encodes a membrane-bound protein that is involved in signal transduction and protein interactions. The encoded product is an E3 ubiquitin-protein ligase, which mediates ubiquitination and subsequent proteasomal degradation of proteins containing phosphotyrosine binding (PTB) domains. This protein may play an important role in tumorogenesis. Alternatively spliced transcript variants encoding distinct isoforms have been described. A pseudogene, which is located on chromosome 17, has been identified for this gene. [provided by RefSeq, Jul 2008]

ExpressionUbiquitous expression in brain (RPKM 10.1), esophagus (RPKM 8.0) and 25 other tissues 

 

Preferred Names

E3 ubiquitin-protein ligase LNX

Names

PDZ domain-containing ring finger protein 2

RING-type E3 ubiquitin transferase LNX

ligand of numb-protein X 1, E3 ubiquitin protein ligase

multi-PDZ-domain-containing protein, E3 ubiquitin-protein ligase LNX

numb-binding protein 1

Related articles in PubMed

1. Suppression of cancer stemness by upregulating Ligand-of-Numb protein X1 in colorectal carcinoma. Ma L, et al. PLoS One, 2017. PMID 29190716, Free PMC Article
2. A global genomic view on LNX siRNA-mediated cell cycle arrest. Zheng D, et al. Mol Biol Rep, 2011 Apr. PMID 21104141
3. Characterization of the amplicon on chromosomal segment 4q12 in glioblastoma multiforme. Holtkamp N, et al. Neuro Oncol, 2007 Jul. PMID 17504929, Free PMC Article
4. Np9 protein of human endogenous retrovirus K interacts with ligand of numb protein X. Armbruester V, et al. J Virol, 2004 Oct. PMID 15367597, Free PMC Article
5. The ligands of Numb proteins X1 and X2 are specific markers for chronic Q fever. Mehraj V, et al. FEMS Immunol Med Microbiol, 2012 Feb. PMID 22066909

See all (50) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

 

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

1. study provided the evidences that LNX1 signaling plays important roles in regulating the stemness of colon cancer cells
2. LNX was closely related to human gliomas and suggested it plays an important role in gliomas by notch signaling.
3. LNX1-mediated ubiquitination and degradation of PBK inhibited cell proliferation and enhanced sensitivity to doxorubicin-induced apoptosis.
4. identify and confirm six novel LNX1 binding partners: KCNA4, PAK6, PLEKHG5, PKC-alpha1, TYK2 and PBK, and suggest that LNX1 functions as a signalling scaffold.
5. The authors found a high level of LNX1 and LNX2 mRNAs in endocarditis, the principal manifestation of chronic Q fever, but not in acute Q fever.
6. LNX1 and LNX2 interact with CD8alpha and promote its ubiquitylation and endocytosis
7. Down-regulation of LNX could result in cell cycle arrest in G0/G1 phase through inhibition of beta-catenin, MAPK, NFkappaB, c-Myc-dependent pathway and activation of p53, TGF-beta-dependent pathway.
8. LNX and RhoC might be part of a larger protein complex that would have important functions in signaling transduction about regulating the transcriptional activities of AP-1.
9. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
10. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)