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onsdag 7 november 2018

Synoviumin proteiinista CHI3L1 eli YKL-40

https://www.ncbi.nlm.nih.gov/protein/NP_001267.2

chitinase-3-like protein 1 precursor [Homo sapiens]

NCBI Reference Sequence: NP_001267.2

LOCUS       NP_001267                383 aa            linear   PRI 21-OCT-2018
DEFINITION  chitinase-3-like protein 1 precursor [Homo sapiens].
ACCESSION   NP_001267
VERSION     NP_001267.2
DBSOURCE    REFSEQ: accession NM_001276.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 383)
  AUTHORS   Geng B, Pan J, Zhao T, Ji J, Zhang C, Che Y, Yang J, Shi H, Li J,
            Zhou H, Mu X, Xu C, Wang C, Xu Y, Liu Z, Wen H and You Q.
  TITLE     Chitinase 3-like 1-CD44 interaction promotes metastasis and
            epithelial-to-mesenchymal transition through beta-catenin/Erk/Akt
            signaling in gastric cancer
  JOURNAL   J. Exp. Clin. Cancer Res. 37 (1), 208 (2018)
   PUBMED   30165890
  REMARK    GeneRIF: CHI3L1 expression is a novel biomarker for the prognosis
            of gastric cancer and these findings have thus identified
            CHI3L1/CD44 axis as a vital pathway and potential therapeutic
            target in gastric cancer
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 383)
  AUTHORS   Salomon J, Piotrowska A, Matusiak L, Dziegiel P and Szepietowski
            JC.
  TITLE     Chitinase-3-like Protein 1 (YKL-40) Expression in Squamous Cell
            Skin Cancer
  JOURNAL   Anticancer Res. 38 (8), 4753-4758 (2018)
   PUBMED   30061245
  REMARK    GeneRIF: YKL-40 is expressed in cutaneous Squamous Cell Skin Cancer
REFERENCE   3  (residues 1 to 383)
  AUTHORS   Rusak A, Jablonska K, Piotrowska A, Grzegrzolka J, Nowak A, Wojnar
            A and Dziegiel P.
  TITLE     The Role of CHI3L1 Expression in Angiogenesis in Invasive Ductal
            Breast Carcinoma
  JOURNAL   Anticancer Res. 38 (6), 3357-3366 (2018)
   PUBMED   29848684
  REMARK    GeneRIF: Results suggest a potential role of chitinase 3 like 1
            protein (CHI3L1) in angiogenesis in invasive ductal breast
            carcinoma (IDC) and may suggest its involvement in cancer
            progression.
REFERENCE   4  (residues 1 to 383)
  AUTHORS   Li XZ, Zhao SC, Cai XL, Wang YF, Chen J, Ma XF and Zhang H.
  TITLE     Differences in expression of YKL-40 and TLR4 in nasal sinus mucosa
            of chronic sinusitis patients with and without nasal polyps
  JOURNAL   J. Biol. Regul. Homeost. Agents 32 (3), 537-543 (2018)
   PUBMED   29921378
  REMARK    GeneRIF: there was a negative correlation between YKL-40 and TLR4
            expression in chronic sinusitis patients with nasal polyps. YKL-40
            and TLR4 interacted with each other to activate NF-kappaB and
            promote disease progression.
REFERENCE   5  (residues 1 to 383)
  AUTHORS   Kulkarni NB, Ganu MU, Godbole SG and Deo SS.
  TITLE     Assessment of potential biomarkers of atherosclerosis in Indian
            patients with type 2 diabetes mellitus
  JOURNAL   Indian J. Med. Res. 147 (2), 169-176 (2018)
   PUBMED   29806605
  REMARK    GeneRIF: Gene expressions of YKL-40 and CD36 were significantly
            higher in patients with T2DM (>5 yr) with hypertension compared to
            healthy controls (P=0.006). In addition, a significant increase in
            serum levels of sCD36, PPAR-gamma and YKL-40 was observed in
            patients with T2DM (>5 yr) with hypertension compared to healthy
            controls
REFERENCE   6  (residues 1 to 383)
  AUTHORS   Renkema GH, Boot RG, Au FL, Donker-Koopman WE, Strijland A,
            Muijsers AO, Hrebicek M and Aerts JM.
  TITLE     Chitotriosidase, a chitinase, and the 39-kDa human cartilage
            glycoprotein, a chitin-binding lectin, are homologues of family 18
            glycosyl hydrolases secreted by human macrophages
  JOURNAL   Eur. J. Biochem. 251 (1-2), 504-509 (1998)
   PUBMED   9492324
REFERENCE   7  (residues 1 to 383)
  AUTHORS   Kirkpatrick RB, Emery JG, Connor JR, Dodds R, Lysko PG and
            Rosenberg M.
  TITLE     Induction and expression of human cartilage glycoprotein 39 in
            rheumatoid inflammatory and peripheral blood monocyte-derived
            macrophages
  JOURNAL   Exp. Cell Res. 237 (1), 46-54 (1997)
   PUBMED   9417865
REFERENCE   8  (residues 1 to 383)
  AUTHORS   Rehli M, Krause SW and Andreesen R.
  TITLE     Molecular characterization of the gene for human cartilage gp-39
            (CHI3L1), a member of the chitinase protein family and marker for
            late stages of macrophage differentiation
  JOURNAL   Genomics 43 (2), 221-225 (1997)
   PUBMED   9244440
REFERENCE   9  (residues 1 to 383)
  AUTHORS   Hakala BE, White C and Recklies AD.
  TITLE     Human cartilage gp-39, a major secretory product of articular
            chondrocytes and synovial cells, is a mammalian member of a
            chitinase protein family
  JOURNAL   J. Biol. Chem. 268 (34), 25803-25810 (1993)
   PUBMED   8245017
REFERENCE   10 (residues 1 to 383)
  AUTHORS   Nyirkos P and Golds EE.
  TITLE     Human synovial cells secrete a 39 kDa protein similar to a bovine
            mammary protein expressed during the non-lactating period
  JOURNAL   Biochem. J. 269 (1), 265-268 (1990)
   PUBMED   2375755
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA167112.1, BC008568.1 and
            AK225266.1.
            This sequence is a reference standard in the RefSeqGene project.
            On Apr 7, 2007 this sequence version replaced NP_001267.1.
            
            Summary: Chitinases catalyze the hydrolysis of chitin, which is an
            abundant glycopolymer found in insect exoskeletons and fungal cell
            walls. The glycoside hydrolase 18 family of chitinases includes
            eight human family members. This gene encodes a glycoprotein member
            of the glycosyl hydrolase 18 family. The protein lacks chitinase
            activity and is secreted by activated macrophages, chondrocytes,
            neutrophils and synovial cells. The protein is thought to play a
            role in the process of inflammation and tissue remodeling.
            [provided by RefSeq, Sep 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK225266.1, SRR1803612.134756.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000350]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..383
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q32.1"
     Protein         1..383
                     /product="chitinase-3-like protein 1 precursor"
                     /note="chitinase-3-like protein 1; 39 kDa synovial
                     protein; cartilage glycoprotein 39; chitinase 3-like 1
                     (cartilage glycoprotein-39)"
                     /calculated_mol_wt=40489
     sig_peptide     1..21
                     /inference="COORDINATES: ab initio prediction:SignalP:4.0"
                     /calculated_mol_wt=2155
     mat_peptide     22..383
                     /product="chitinase-3-like protein 1"
                     /calculated_mol_wt=40489
     Region          23..357
                     /region_name="Glyco_18"
                     /note="Glyco_18 domain; smart00636"
                     /db_xref="CDD:214753"
     Region          24..380
                     /region_name="GH18_chitolectin_chitotriosidase"
                     /note="This conserved domain family includes a large
                     number of catalytically inactive chitinase-like lectins
                     (chitolectins) including YKL-39, YKL-40 (HCGP39), YM1,
                     oviductin, and AMCase (acidic mammalian chitinase), as
                     well as catalytically active...; cd02872"
                     /db_xref="CDD:119351"
     Site            order(27,31,99..100,138,140..141,180..181,204,206..207,
                     212,261,263,290,352)
                     /site_type="active"
                     /db_xref="CDD:119351"
     Region          70..71
                     /region_name="Chitooligosaccharide binding"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P36222.2)"
     Region          97..100
                     /region_name="Chitooligosaccharide binding"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P36222.2)"
     Region          204..207
                     /region_name="Chitooligosaccharide binding"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P36222.2)"
     Region          324..338
                     /region_name="Important for AKT1 activation and IL8
                     production. {ECO:0000250}"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P36222.2)"
     CDS             1..383
                     /gene="CHI3L1"
                     /gene_synonym="ASRT7; CGP-39; GP-39; GP39; HC-gp39;
                     hCGP-39; HCGP-3P; YK-40; YKL-40; YKL40; YYL-40"
                     /coded_by="NM_001276.2:172..1323"
                     /db_xref="CCDS:CCDS1435.1"
                     /db_xref="GeneID:1116"
                     /db_xref="HGNC:HGNC:1932"
                     /db_xref="MIM:601525"
ORIGIN      
        1 mgvkasqtgf vvlvllqccs ayklvcyyts wsqyregdgs cfpdaldrfl cthiiysfan
       61 isndhidtwe wndvtlygml ntlknrnpnl ktllsvggwn fgsqrfskia sntqsrrtfi
      121 ksvppflrth gfdgldlawl ypgrrdkqhf ttlikemkae fikeaqpgkk qlllsaalsa
      181 gkvtidssyd iakisqhldf isimtydfhg awrgttghhs plfrgqedas pdrfsntdya
      241 vgymlrlgap asklvmgipt fgrsftlass etgvgapisg pgipgrftke agtlayyeic
      301 dflrgatvhr ilgqqvpyat kgnqwvgydd qesvkskvqy lkdrqlagam vwaldlddfq
      361 gsfcgqdlrf pltnaikdal aat
//

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