chitinase-3-like protein 1 precursor [Homo sapiens]
NCBI Reference Sequence: NP_001267.2
LOCUS NP_001267 383 aa linear PRI 21-OCT-2018 DEFINITION chitinase-3-like protein 1 precursor [Homo sapiens]. ACCESSION NP_001267 VERSION NP_001267.2 DBSOURCE REFSEQ: accession NM_001276.2 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (residues 1 to 383) AUTHORS Geng B, Pan J, Zhao T, Ji J, Zhang C, Che Y, Yang J, Shi H, Li J, Zhou H, Mu X, Xu C, Wang C, Xu Y, Liu Z, Wen H and You Q. TITLE Chitinase 3-like 1-CD44 interaction promotes metastasis and epithelial-to-mesenchymal transition through beta-catenin/Erk/Akt signaling in gastric cancer JOURNAL J. Exp. Clin. Cancer Res. 37 (1), 208 (2018) PUBMED 30165890 REMARK GeneRIF: CHI3L1 expression is a novel biomarker for the prognosis of gastric cancer and these findings have thus identified CHI3L1/CD44 axis as a vital pathway and potential therapeutic target in gastric cancer Publication Status: Online-Only REFERENCE 2 (residues 1 to 383) AUTHORS Salomon J, Piotrowska A, Matusiak L, Dziegiel P and Szepietowski JC. TITLE Chitinase-3-like Protein 1 (YKL-40) Expression in Squamous Cell Skin Cancer JOURNAL Anticancer Res. 38 (8), 4753-4758 (2018) PUBMED 30061245 REMARK GeneRIF: YKL-40 is expressed in cutaneous Squamous Cell Skin Cancer REFERENCE 3 (residues 1 to 383) AUTHORS Rusak A, Jablonska K, Piotrowska A, Grzegrzolka J, Nowak A, Wojnar A and Dziegiel P. TITLE The Role of CHI3L1 Expression in Angiogenesis in Invasive Ductal Breast Carcinoma JOURNAL Anticancer Res. 38 (6), 3357-3366 (2018) PUBMED 29848684 REMARK GeneRIF: Results suggest a potential role of chitinase 3 like 1 protein (CHI3L1) in angiogenesis in invasive ductal breast carcinoma (IDC) and may suggest its involvement in cancer progression. REFERENCE 4 (residues 1 to 383) AUTHORS Li XZ, Zhao SC, Cai XL, Wang YF, Chen J, Ma XF and Zhang H. TITLE Differences in expression of YKL-40 and TLR4 in nasal sinus mucosa of chronic sinusitis patients with and without nasal polyps JOURNAL J. Biol. Regul. Homeost. Agents 32 (3), 537-543 (2018) PUBMED 29921378 REMARK GeneRIF: there was a negative correlation between YKL-40 and TLR4 expression in chronic sinusitis patients with nasal polyps. YKL-40 and TLR4 interacted with each other to activate NF-kappaB and promote disease progression. REFERENCE 5 (residues 1 to 383) AUTHORS Kulkarni NB, Ganu MU, Godbole SG and Deo SS. TITLE Assessment of potential biomarkers of atherosclerosis in Indian patients with type 2 diabetes mellitus JOURNAL Indian J. Med. Res. 147 (2), 169-176 (2018) PUBMED 29806605 REMARK GeneRIF: Gene expressions of YKL-40 and CD36 were significantly higher in patients with T2DM (>5 yr) with hypertension compared to healthy controls (P=0.006). In addition, a significant increase in serum levels of sCD36, PPAR-gamma and YKL-40 was observed in patients with T2DM (>5 yr) with hypertension compared to healthy controls REFERENCE 6 (residues 1 to 383) AUTHORS Renkema GH, Boot RG, Au FL, Donker-Koopman WE, Strijland A, Muijsers AO, Hrebicek M and Aerts JM. TITLE Chitotriosidase, a chitinase, and the 39-kDa human cartilage glycoprotein, a chitin-binding lectin, are homologues of family 18 glycosyl hydrolases secreted by human macrophages JOURNAL Eur. J. Biochem. 251 (1-2), 504-509 (1998) PUBMED 9492324 REFERENCE 7 (residues 1 to 383) AUTHORS Kirkpatrick RB, Emery JG, Connor JR, Dodds R, Lysko PG and Rosenberg M. TITLE Induction and expression of human cartilage glycoprotein 39 in rheumatoid inflammatory and peripheral blood monocyte-derived macrophages JOURNAL Exp. Cell Res. 237 (1), 46-54 (1997) PUBMED 9417865 REFERENCE 8 (residues 1 to 383) AUTHORS Rehli M, Krause SW and Andreesen R. TITLE Molecular characterization of the gene for human cartilage gp-39 (CHI3L1), a member of the chitinase protein family and marker for late stages of macrophage differentiation JOURNAL Genomics 43 (2), 221-225 (1997) PUBMED 9244440 REFERENCE 9 (residues 1 to 383) AUTHORS Hakala BE, White C and Recklies AD. TITLE Human cartilage gp-39, a major secretory product of articular chondrocytes and synovial cells, is a mammalian member of a chitinase protein family JOURNAL J. Biol. Chem. 268 (34), 25803-25810 (1993) PUBMED 8245017 REFERENCE 10 (residues 1 to 383) AUTHORS Nyirkos P and Golds EE. TITLE Human synovial cells secrete a 39 kDa protein similar to a bovine mammary protein expressed during the non-lactating period JOURNAL Biochem. J. 269 (1), 265-268 (1990) PUBMED 2375755 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA167112.1, BC008568.1 and AK225266.1. This sequence is a reference standard in the RefSeqGene project. On Apr 7, 2007 this sequence version replaced NP_001267.1. Summary: Chitinases catalyze the hydrolysis of chitin, which is an abundant glycopolymer found in insect exoskeletons and fungal cell walls. The glycoside hydrolase 18 family of chitinases includes eight human family members. This gene encodes a glycoprotein member of the glycosyl hydrolase 18 family. The protein lacks chitinase activity and is secreted by activated macrophages, chondrocytes, neutrophils and synovial cells. The protein is thought to play a role in the process of inflammation and tissue remodeling. [provided by RefSeq, Sep 2009]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK225266.1, SRR1803612.134756.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## FEATURES Location/Qualifiers source 1..383 /organism="Homo sapiens" /db_xref="taxon:9606" /chromosome="1" /map="1q32.1" Protein 1..383 /product="chitinase-3-like protein 1 precursor" /note="chitinase-3-like protein 1; 39 kDa synovial protein; cartilage glycoprotein 39; chitinase 3-like 1 (cartilage glycoprotein-39)" /calculated_mol_wt=40489 sig_peptide 1..21 /inference="COORDINATES: ab initio prediction:SignalP:4.0" /calculated_mol_wt=2155 mat_peptide 22..383 /product="chitinase-3-like protein 1" /calculated_mol_wt=40489 Region 23..357 /region_name="Glyco_18" /note="Glyco_18 domain; smart00636" /db_xref="CDD:214753" Region 24..380 /region_name="GH18_chitolectin_chitotriosidase" /note="This conserved domain family includes a large number of catalytically inactive chitinase-like lectins (chitolectins) including YKL-39, YKL-40 (HCGP39), YM1, oviductin, and AMCase (acidic mammalian chitinase), as well as catalytically active...; cd02872" /db_xref="CDD:119351" Site order(27,31,99..100,138,140..141,180..181,204,206..207, 212,261,263,290,352) /site_type="active" /db_xref="CDD:119351" Region 70..71 /region_name="Chitooligosaccharide binding" /experiment="experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (P36222.2)" Region 97..100 /region_name="Chitooligosaccharide binding" /experiment="experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (P36222.2)" Region 204..207 /region_name="Chitooligosaccharide binding" /experiment="experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (P36222.2)" Region 324..338 /region_name="Important for AKT1 activation and IL8 production. {ECO:0000250}" /experiment="experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (P36222.2)" CDS 1..383 /gene="CHI3L1" /gene_synonym="ASRT7; CGP-39; GP-39; GP39; HC-gp39; hCGP-39; HCGP-3P; YK-40; YKL-40; YKL40; YYL-40" /coded_by="NM_001276.2:172..1323" /db_xref="CCDS:CCDS1435.1" /db_xref="GeneID:1116" /db_xref="HGNC:HGNC:1932" /db_xref="MIM:601525" ORIGIN 1 mgvkasqtgf vvlvllqccs ayklvcyyts wsqyregdgs cfpdaldrfl cthiiysfan 61 isndhidtwe wndvtlygml ntlknrnpnl ktllsvggwn fgsqrfskia sntqsrrtfi 121 ksvppflrth gfdgldlawl ypgrrdkqhf ttlikemkae fikeaqpgkk qlllsaalsa 181 gkvtidssyd iakisqhldf isimtydfhg awrgttghhs plfrgqedas pdrfsntdya 241 vgymlrlgap asklvmgipt fgrsftlass etgvgapisg pgipgrftke agtlayyeic 301 dflrgatvhr ilgqqvpyat kgnqwvgydd qesvkskvqy lkdrqlagam vwaldlddfq 361 gsfcgqdlrf pltnaikdal aat //
