LNX4 (12q12) PDZRN4, SAMCAP3L,Ligand of Numb protein X4 (antituumoriproteiini)

https://www.ncbi.nlm.nih.gov/gene/29951

Also known as

LNX4; SAMCAP3L

Expression

Broad expression in prostate (RPKM 5.3), urinary bladder (RPKM 3.3) and 15 other tissues See more

Orthologs mouse all

Preferred Names

PDZ domain-containing RING finger protein 4

Names

IMAGE5767589

SEMACAP3-like protein

ligand of Numb protein X 4

Structure, history

https://www.ncbi.nlm.nih.gov/protein/NP_001158067.1

 

Conserved Domains (4) summary

smart00228
Location:221 → 313

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00162
Location:17 → 5

40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

cd00992
Location:402 → 484

PDZ_signaling; PDZ do

responi

d binding to internal (non-C-terminal) ...

cl19105
Location:66 → 108

Sina; Seven in absentia (Sina) protein family, C-terminal substrate binding domain; composed of the Drosophila Sina protein, the mammalian Sina homolog (Siah), the plant protein SINAT5, and similar proteins. Sina, Siah and SINAT5 are RING-containing proteins ...

Related articles in PubMed

1. PDZRN4 acts as a suppressor of cell proliferation in human liver cancer cell lines. Hu T, et al. Cell Biochem Funct, 2015 Oct. PMID 26486104
2. Identification and characterization of PDZRN3 and PDZRN4 genes in silico. Katoh M, et al. Int J Mol Med, 2004 Apr. PMID 15010864
3. A genome-wide association study identifies susceptibility loci of silica-related pneumoconiosis in Han Chinese. Chu M, et al. Hum Mol Genet, 2014 Dec 1. PMID 24986923
4. Replication of top markers of a genome-wide association study in multiple sclerosis in Spain. Cavanillas ML, et al. Genes Immun, 2011 Mar. PMID 20944657
5. Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis. Baranzini SE, et al. Hum Mol Genet, 2009 Feb 15. PMID 19010793, Free PMC Article

See all (15) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

1. Results showed that PDZRN4 might be a potential tumour suppressor gene and had anti-proliferative effect on hepatocellular carcinoma cell proliferation.
2. Observational study of gene-disease association. (HuGE Navigator)

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