LNX3 (3p13) PDZRN3, SEMCAP3 ( HPV virus E6p tuhonnee tämän proteiinin)

https://www.ncbi.nlm.nih.gov/gene/23024

LNX3; SEMCAP3; SEMACAP3

Summary

This gene encodes a member of the LNX (Ligand of Numb Protein-X) family of RING-type ubiquitin E3 ligases. This protein may function in vascular morphogenesis and the differentiation of adipocytes, osteoblasts and myoblasts. This protein may be targeted for degradation by the human papilloma virus E6 protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]

Expression

Broad expression in ovary (RPKM 21.4), endometrium (RPKM 16.6) and 20 other tissues See more

Orthologs mouse all

 

Preferred Names

E3 ubiquitin-protein ligase PDZRN3

Names

RING-type E3 ubiquitin transferase PDZRN3

ligand of Numb protein X 3

likely ortholog of mouse semaF cytoplasmic domain associated protein 3

semaphorin cytoplasmic domain-associated protein 3

NP_001290068.1

• EC 2.3.2.27

 Structure, history:

 NP_00129008.1  E3 ubiquitin-protein ligase PDZRN3 isoform 2

Conserved Domains (2) summary

smart00228
Location:5 → 36

PDZ; Domain pres

nt in PSD-95, Dlg, and ZO-1/2

cd00992
Location:118 → 186

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein int

ractions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terin) ...

Related articles in PubMed

1. 3p interstitial deletion: novel case report and review. Ţuţulan-Cunită AC, et al. J Child Neurol, 2012 Aug. PMID 22290856
2. Molecular evolution of the LNX gene family. Flynn M, et al. BMC Evol Biol, 2011 Aug 9. PMID 21827680, Free PMC Article
3. Gene expression profiles in primary ovarian serous papillary tumors and normal ovarian epithelium: identification of candidate molecular markers for ovarian cancer diagnosis and therapy. Santin AD, et al. Int J Cancer, 2004 Oct 20. PMID 15305371
4. PDZRN3/LNX3 is a novel target of human papillomavirus type 16 (HPV-16) and HPV-18 E6. Thomas M, et al. J Virol, 2015 Jan 15. PMID 25355882, Free PMC Article
5. Regulation of adipocyte differentiation of 3T3-L1 cells by PDZRN3. Honda T, et al. Am J Physiol Cell Physiol, 2013 Jun 1. PMID 23576576

See all (30) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

1. Authors show that HPV-16 and HPV-18 E6 can target PDZRN3 in a PDZ- and proteasome-dependent manner and provide a connection between the papillomavirus life cycle and differentiation-related STAT signaling.
2. a novel partner of Kidins220/ARMS
3. These results indicate that PDZRN3 plays an important role in negative feedback control of BMP-2-induced osteoblast differentiation in C2C12 cells through inhibition of Wnt3a-beta-catenin signaling.
4. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
5. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)

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